Koi Herpesvirus Disease in Japan

東京海洋大学名誉教

p59fyn is associated with the development of hepatic steatosis due to chronic ethanol consumption

p59fyn, a protein tyrosine kinase belonging to the src-family, is involved in the regulatory mechanism of acute response to ethanol in the central nervous system. A previous report showed an association between src-family kinase activity and fatty acid oxidation, and it also reported that hepatic free fatty acid levels were low in Fyn−/− mice. We examined, using Fyn−/− mice whether Fyn is also involved in fatty acid metabolism and the development of pathological changes in the liver in response to chronic ethanol consumption. C57BL/6J Fyn−/− and Fyn+/+ mice were fed for 8 weeks with either a liquid diet comprising ethanol or one in which the calories from ethanol were replaced with carbohydrates. Chronic ethanol consumption for 8 weeks resulted in remarkable hepatic steatosis in Fyn+/+ mice but not in Fyn−/− mice. Chronic ethanol consumption induced a significant decrease in hepatic FFA and triglyceride levels in Fyn−/− mice. Levels of interleukin-6, which is associated with the enhancement of fatty acid oxidation, was also increased significantly in the livers of ethanol-fed Fyn−/− mice. The results suggest that Fyn is involved in the enhancement of fatty acid oxidation and the development of hepatic steatosis caused by chronic ethanol consumption

Lepton Flavor Violation in Supersymmetric SO(10) Grand Unified Models

The study for lepton flavor violation combined with the neutrino oscillation may provide more information about the lepton flavor structure of the grand unified theory. In this paper, we study two lepton flavor violation processes, $\tau\to \mu\gamma$ and $Z\to \tau\mu$, in the context of supersymmetric SO(10) grand unified models. We find the two processes are both of phenomenological interest. In particular the latter may be important in some supersymmetric parameter space where the former is suppressed. Thus, Z-dacay may offer another chance for looking for lepton flavor violation.Comment: 26 pages, 10 figure

Area of Compaction to Prevent Uplift by Liquefaction

In this study, shaking table tests, upper seepage flow tests and numerical analyses were conducted to determine the condition of improvement by the compaction method, including the extent of area and the density, to prevent uplift of underground pipes by liquefaction. Based on the results of these investigations, a procedure to determine the improvement conditions was proposed

Outer Membrane Vesicles of Helicobacter pylori TK1402 are Involved in Biofilm Formation

<p>Abstract</p> <p>Background</p> <p><it>Helicobacter pylori </it>forms biofilms on glass surfaces at the air-liquid interface in <it>in vitro </it>batch cultures; however, biofilms of <it>H. pylori </it>have not been well characterized. In the present study, we analyzed the ability of <it>H. pylori </it>strains to form biofilms and characterized the underlying mechanisms of <it>H. pylori </it>biofilm formation.</p> <p>Results</p> <p>Strain TK1402 showed strong biofilm forming ability relative to the other strains in Brucella broth supplemented with 7% FCS. The strong biofilm forming ability of TK1402 is reflected the relative thickness of the biofilms. In addition, outer membrane vesicles (OMV) were detected within the matrix of only the TK1402 biofilms. Biofilm formation was strongly correlated with the production of OMV in this strain. We further observed that strain TK1402 did not form thick biofilms in Brucella broth supplemented with 0.2% β-cyclodextrin. However, the addition of the OMV-fraction collected from TK1402 could enhance biofilm formation.</p> <p>Conclusion</p> <p>The results suggested that OMV produced from TK1402 play an important role in biofilm formation in strain TK1402.</p

Lepton Flavor Violating Z Decays in the Zee Model

We calculate lepton flavor violating (LFV) Z decays Z \to {{e_i^\pm}}e_j^\mp (i, j = e, \mu, \tau ; i\neq j) in the Zee model keeping in view the radiative leptonic decays e_i\to e_j\gamma (i = \mu, \tau ; j = e, \mu ; i\neq j), \mu decay and anomalous muon magnetic moment (\mu AMM). We investigate three different cases of Zee f_{ij} coupling (A) f_{e\mu}^2 = f_{\mu\tau}^2= f_{\tau e}^2, (B) f_{e\mu}^2 \gg f_{\tau e}^2 \gg f_{\mu\tau}^2, and (C) f_{\mu\tau}^2 \gg f_{e\mu}^2 \gg f_{\tau e}^2 subject to the neutrino phenomenology. Interestingly, we find that, although the case (C) satisfies the large excess value of \mu AMM, however, it is unable to explain the solar neutrino experimental result, whereas the case (B) satisfies the bi-maximal neutrino mixing scenario, but confronts with the result of \mu AMM experiment. We also find that among all the three cases, only the case (C) gives rise to largest contribution to the ratio B(Z\to e^\pm\tau^\mp)/B(Z\to \mu^\pm \mu^\mp) \simeq {10}^{-8} which is still two order less than the accessible value to be probed by the future linear colliders, whereas for the other two cases, this ratio is too low to be observed even in the near future for all possible LFV Z decay modes.Comment: 12 pages, RevTex, 2 figures, 3 Tables, typos corrected, reference added, version to appear in Phys. Rev.

Evolution of the Yukawa coupling constants and seesaw operators in the universal seesaw model

The general features of the evolution of the Yukawa coupling constants and seesaw operators in the universal seesaw model with det M_F=0 are investigated. Especially, it is checked whether the model causes bursts of Yukawa coupling constants, because in the model not only the magnitude of the Yukawa coupling constant (Y_L^u)_{33} in the up-quark sector but also that of (Y_L^d)_{33} in the down-quark sector is of the order of one, i.e., (Y_L^u)_{33} \sim (Y_L^d)_{33} \sim 1. The requirement that the model should be calculable perturbatively puts some constraints on the values of the intermediate mass scales and tan\beta (in the SUSY model).Comment: 21 pages, RevTex, 10 figure